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Paediatric Intensive Care Unit (PICU)

Research

  • Paediatric intensive care research is an exciting field, which addresses a spectrum of diseases and conditions which continue to challenge our critically ill children. The Royal Children's Hospital intensive care research team are delighted to be part of a number of national and international collaborative studies, as well as undertaking local projects. Our areas of particular interest include cardiac disease, acquired brain injury, lung injury and renal replacement therapy.

    All intensive care staff are encouraged to undertake research, and in addition we have a dedicated group of nurses who together co-ordinate our research projects. This enables us to efficiently screen all children admitted to the unit, each day, for their suitability for inclusion in our projects.

    PICU Data Quality and research staff

    All staff from medical, nursing and technology departments within the intensive care unit are encouraged to undertake research. The skills and experience of the intensive care consultant group have provided a strong foundation for the continued growth of research within the unit.

    Staff involved in research are assisted by:

    Data, Quality and Audit Team 

    Carmel Delzoppo

    Manager of the Intensive Care Database and responsible for the development, implementation and maintenance of the clinical database in intensive care, and for producing reports and statistics for use in research within the hospital and externally, with particular reference to the collaborative effort with Australian and New Zealand Paediatric Intensive Care Registry. Team leader of the collaborative data and research team.            

    Intensive Care Research Co-ordinator, responsible for monitoring and co-ordinating research projects in the intensive care unit and liasing with staff interested in performing research. Carmel also Manages PICU reporting from the intensive care database for the purpose of decision support, quality, auditing and research. Steering Committee member for the Paediatric Study Group in the Clinical trials Group for Australian and New Zealand Intensive Care Society.                                                                          

    Telephone: 61 3 9345 4766  
    e-mail: carmel.delzoppo@rch.org.au

    Andrea Veysey

    Intensive Care Research Co-ordinator, responsible for set up performing, monitoring and coordinating research projects in the intensive care unit and liaising with staff interested in performing research. Producing reports and statistics for use in research within the hospital and externally.

    Telephone: 61 3 9345 6755
    e-mail: andrea.veysey@rch.org.au

    Kate Masterson, Alyssa Serratore, Jessica Appleyard, Andrea Sheffield

    Intensive Care Research Co-Ordinators, responsible for set up performing, monitoring and coordinating research projects in the intensive care unit and liaising with staff interested in performing research.

    PICU Research pager: 5406

    email: kate.masterson@rch.org.au, Alyssa.serratore@rch.org.au, jessica.appleyard@rch.org, andrea.sheffield@rch.org.au

    Anna Butlinski

    Senior Research Officer MCRI and Senior Research Officer RCH (Honorary), responsible for initiating and conducting research in intensive care focusing on child abuse and neglect.

    email: anna.butlinski@rch.org.au 

    Claire Daffey, Liz Fletcher, Linda Darragh

    Database and Research Assistants contribute to data collection, maintenance of the intensive care database, audits and clinical research projects. The team also perform PICU patient outcome calls.

    Telephone: 61 3 9345 4766, or ICU data room: 54064 
    e-mail:  claire.daffey@rch.org.au, liz.fletcher@rch.org.au, linda.darragh@rch.org.au

    Murdoch Affiliated Research Coordinators

    Carmel Delzoppo, Jenny Thompson, Kate Masterson, Alyssa Serratore, Jessica Appleyard, Andrea Sheffield, Anna Butlinksi

    Research currently running in PICU

    1.       Nitric Oxide during Cardio Pulmonary Bypass during surgery for congenital heart defects: A Randomised Controlled Trial

    2.       A randomised controlled trial of nitric oxide administration during cardiopulmonary bypass in infants undergoing Arterial Switch Operation for repair of transposition of the great arteries.

    3.       Trans-nasal Humidified Rapid- Insufflation Ventilatory Exchange in Children Requiring Emergent Intubation

    4.       Early prophylactic peritoneal dialysis in infants post cardiac surgery: a randomised, open, two group trial

    5.       PRone and OScillation PEdiatric Clinical Trial.

    6.       Safety Study of Autologous Cord Blood Stem Cell Treatment in Hypoplastic Left Heart Syndrome Patients Undergoing the Norwood Heart Operation.

    7.       An Ongoing Long term year follow up of functional and quality outcomes for children admitted to the Paediatric Intensive Care Unit (PICU).

    8.       ANZICS Point prevalence project.

    9.       Evaluation of an ECLS nurse-led anticoagulation protocol: a before & after study.

    10.   The addition of a sub study the approved ADAPT project.  “Magnetic Resonance Imaging (MRI) Markers of Outcome after Severe Pediatric Traumatic Brain Injury (TBI)” 

    11.   Comparison of function and quality scores as an outcome assessment after Paediatric Intensive Care (PICU Outcomes).

    12.   Parent reported levels of satisfaction with care provided in PICU.

    13.   Evaluation of psychological needs and support program in PICU. 

    14.   The VANcomycin Cohort study – Assessing Precise dosing and Prompt drug monitoring to improve attainment of target concentrations (VANC APP)

    15.   Flucloxacillin pharmacokinetics in children.

    16.   Haemodynamic response to fluid boluses in children in a PICU

    17.   Patterns of 4% albumin fluid boluses in a paediatric and general intensive care unit

    18.   ANZICS Paediatric Study Group prioritisation study: establishing the research priorities of paediatric intensive care physicians in Australia and New Zealand.

    19.   Testing the Accuracy of a Malignant Pertussis Prediction Model- A Prospective Observational Cohort Study

    20.   Resilience and Burnout in PICU Nurses: An Australian Experience. 

    Data reviews and Audits:

    1.     Prevalence, severity and outcomes of severe infections in critically ill children in Australia and New Zealand in the era of sepsis-3 - a prospective study of the Australian and New Zealand paediatric intensive care registry.

    2.     Time of admission to paediatric ICU and its association with outcomes: an analysis of the Australian and New Zealand Paediatric Intensive Care Registry database.

    3.     Time of discharge from paediatric ICU and its association with outcomes: an analysis of the Australian and New Zealand Paediatric Intensive Care Registry database.

    4.     Changing outcomes for children with oncological diagnosis admitted to PICUs: an analysis of the Australian and New Zealand Paediatric Intensive Care Registry database.

    5.     The role of hypothermia in influencing long-term outcomes after cardiac arrest in children. Clinical Benefits of Nitric Oxide Added to the Oxygenator of Children on ECMO.

    6.     Acquired infections and complications in children who received Extracorpreal membrane oxygenation. Risk factors and outcomes.

    7.     Characteristics of patients who had the cardiac call out and required extracorporeal membrane oxygenation (ECMO) compared to those children who did not require ECMO.

    8.     Clinical Audit of Extubation Outcomes

    9.     ECMO (Extracorporeal membrane oxygenation) for Sepsis.

    10.   Indication for ECMO: Arrest; LCOS; Arrhythmia Location to go on ECMO: ICU or OR Open chest versus closed chest.

    11.   Characteristics of blood sampling practice.

    12.   Risk factors for intensive care therapy following a MET event in a quaternary children’s hospital

    13.   Adverse events and their implications on PICU: a prospective study.

    14.   Retrospective study of the clinical features and management of children with Para pneumonic effusions and empyema admitted to PICU.

    15.   Critical bone and joint infections: a retrospective case-series of children admitted to a single intensive care unit with severe bone and joint infections.

    16.   Changes in the treatment and disposition of patients with bronchiolitis over the last 10 years.

    17.   Kate Lambert: PICU extubation outcomes

    18.   ARDS in Children and ECMO initiation strategies impact on Neuro-Development (ASCEND)

    19.   ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease. The ECMOCARD Trial.

    20.   The effect and safety of humidified high-flow nasal cannula on the interhospital transport for children with respiratory illness

    21.   Short Period Incidence study of Severe Acute Respiratory Infection (SPRINT-SARI)_COVD19

    Published works 2020

    Duke T., Wong NX. - Antimicrobial resistance: think globally but act locally. Arch Dis Child. 105(1):1-3, 2020 Jan.

    Brooks K.S., Tan L.H., Rozen T.H., Kelly D., McKenzie D.P., Calafiore P., Barrett J. Validation of Epworth Richmond's Echocardiography Education Focused Year. Critical care medicine. 48 (1) (pp e34-e39), 2020. Date of Publication: 01 Jan 2020. http://dx.doi.org/10.1097/CCM.0000000000004076

    Graham H., Bakare A.A., Fashanu C., Wiwa O., Duke T.,Falade A.G. Oxygen therapy for children: A key tool in reducing deaths from pneumonia.  Pediatric pulmonology. (no pagination), 2020. Date of Publication: 21 Jan 2020. http://dx.doi.org/10.1002/ppul.24656

    Tosif S., Jatobatu A., Maepio A., Gray A., Gilbert K., Hodgson J., Duke T. Implementation Lessons from a Multifaceted National Newborn Program in Solomon Islands: A Mixed-Methods Study. The Am J Trop Med Hyg. 102(3):667-675, 2020 Mar.. - http://dx.doi.org/10.4269/ajtmh.19-0631

    Duke T. Lessons from demographic and health surveys on child health and the sustainable development goals: call for papers. Archives of disease in childhood. (no pagination), 2020. Date of Publication: 20 Jan 2020. - http://dx.doi.org/10.1136/archdischild-2019-318353

    Pham H., Thompson J., Wurzel D., Duke T. Ten years of severe respiratory syncytial virus infections in a tertiary paediatric intensive care unit. - Journal of Paediatrics and Child Health. 56 (1) (pp 61-67), 2020. Date of Publication: 01 Jan 2020. - http://dx.doi.org/10.1111/jpc.14491

    Bakare A.A., Graham H., Ayede A.I., Peel D., Olatinwo O., Oyewole O.B., Fowobaje K.R., Qazi S.,  Izadnegahdar R., Duke T., Falade A.G. Providing oxygen to children and newborns: a multi-faceted

    technical and clinical assessment of oxygen access and oxygen use in secondary-level hospitals in southwest Nigeria. International health. 12 (1) (pp 60-68), 2020. Date of Publication: 01 Jan 2020.

    - http://dx.doi.org/10.1093/inthealth/ihz009

    Abo Y.-N., Curtis N., Butters C., Rozen T.H., Marais B.J., Gwee A. Successful treatment of a severe vision-threatening  paradoxical tuberculous reaction with infliximab: first pediatric use. The Pediatric infectious disease journal. (no pagination), 2020. Date of Publication: 13 Jan 2020. - http://dx.doi.org/10.1097/INF.0000000000002578

    Brooks KS.,  Tan LH., Rozen TH., Kelly D., McKenzie DP., Calafiore P., Barrett J. Validation of Epworth Richmond's Echocardiography Education Focused Year. Critical Care Medicine. 48(1):e34-e39, 2020 Jan. - https://dx.doi.org/10.1097/CCM.0000000000004076

    Duke T.,Wong N.X. Antimicrobial resistance: Think globally but act locally. Archives of Disease in Childhood. 105 (1) (pp 1-3), 2020. Date of Publication: 01 Jan 2020. http://dx.doi.org/10.1136/archdischild-2019-317953

    Schlapbach LJ, Chatfield M, Rycus P, MacLaren G. Extracorporeal membrane oxygenation for Group B Streptococcal sepsis in neonates – a retrospective study of the Extracorporeal Life Support Organization Registry. Pediatr Crit Care Med [in press] (Impact factor 2.8)

    Ramanathan KR, Tan CS, Rycus P, Anders M, Lorusso R, Zhang J, MacLaren G. Extracorporeal membrane oxygenation in pregnancy: an analysis of the ELSO Registry. Critical Care Medicine. 48(5):696-703, 2020 May (Impact factor 7.0) https://dx.doi.org/10.1097/CCM.0000000000004269

    Weiss SL, Peters MJ, Alhazzani W, Agus MS, Flori HR, Inwald D, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol E, Carroll C, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KF, Joshi P, Karam O, Kneyber MC, Lemson J, MacLaren G, Mehta NM, Moller MH, Newth CJ, Nguyen T, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HE, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med [in press] (Impact factor 19.0)

    Weiss SL, Peters MJ, Alhazzani W, Agus MS, Flori HR, Inwald D, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol E, Carroll C, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KF, Joshi P, Karam O, Kneyber MC, Lemson J, MacLaren G, Mehta NM, Moller MH, Newth CJ, Nguyen T, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HE, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the management of septic shock and sepsis-associated organ dysfunction in children Pediatr Crit Care Med [in press] (Impact factor 2.8)

    Weiss, S.L., et al. [Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children', Intensive Care Medicine 2020; vol.46(Suppl. 1), pp.S1-9

    Weiss, S.L., et al. [Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children', Intensive Care Medicine 2020; vol.46(Suppl. 1), pp.S10-67

    Zhang JY, Ong JA, Syn NL, Lorusso R, Tan CS, MacLaren G, Ramanathan KR. Extracorporeal membrane oxygenation in pregnancy and postpartum women: a systematic review and meta-regression analysis. J Intensive Care Med [Epub ahead of print] (Impact factor 2.9)

    MacLaren G, Brown K, Thiagarajan RR. What's new in paediatric extracorporeal life support? Intensive Care Med [Epub ahead of print] (Impact factor 19.0)

    MacLaren G, Schlapbach LJ, Aiken A. Nosocomial infections during extracorporeal membrane oxygenation in neonatal, pediatric, and adult patients: A comprehensive narrative review. Pediatr Crit Care Med [Epub ahead of print] (Impact factor 2.8)

    Jen WY, Kristanto W, Teo L, Phua J, Yip HW, MacLaren G, Teoh K, Beng ST, Loh J, Ong CC, Chee YL, Kojodjojo P. Assessing the impact of a pulmonary embolism response team and treatment protocol on patients presenting with pulmonary embolism. Heart Lung Circ 2019 [Epub ahead of print] (Impact factor 2.1)

    MacLaren G, Masoumi A, Brodie D. ECPR for out-of-hospital cardiac arrest: more evidence is needed. - Critical Care. 24 (1) (no pagination), 2020. Article Number: 7. Date of Publication: 07 Jan 2020. (Impact factor 7.0) - http://dx.doi.org/10.1186/s13054-019-2722-0

    MacLaren G, Monagle P. Platelet transfusion during extracorporeal membrane oxygenation: possible harm, ongoing uncertainty. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 21 (2) (pp 208-209), 2020.02. Date of Publication: 01 Feb 2020. (Impact factor 2.8) https://dx.doi.org/10.1097/PCC.0000000000002111

    Li C., Clifford M. Dexmedetomidine Infusion Overdose during Anaesthesia: A Case Report. Paediatr Anaesth. 30(2):191-193, 2020 Feb. - http://dx.doi.org/10.1111/pan.13801

    Ramanathan KR, Biswabikash M, Tang S, MacLaren G. Extracorporeal therapy for amlodipine poisoning. J Artif Organs [Epub ahead of print] (Impact factor 1.5)

    Shime N, MacLaren G. Is broad-spectrum antimicrobial prophylaxis ideal for open-chest management? Pediatric Critical Care Medicine. 21(3):301-302, 2020 Mar. (Impact factor 2.8) https://dx.doi.org/10.1097/PCC.0000000000002215

    Barbaro RP., MacLaren G. Improving Pediatric Extracorporeal Cardiopulmonary Resuscitation Means Delivering Best Care and Measuring Impact Beyond Survival. Critical Care Medicine. 47(4):613-615, 2019 04. - https://dx.doi.org/10.1097/CCM.0000000000003673

    Tosif S., Jatobatu A., Maepioh A., Gray A., Sobel H., Mannava P., Duke T. Healthcare worker knowledge and skills following coaching in WHO early essential newborn care program in the Solomon Islands: a
    prospective multi-site cohort study. BMC Pregnancy Childbirth. 20(1):84, 2020 Feb 07. https://dx.doi.org/10.1186/s12884-020-2739-z

    Long E., Babl FE., Oakley E., Hopper S., Sheridan B., Duke T. Does fluid bolus therapy increase blood pressure in children with sepsis? Emergency Medicine Australasia. 32 (1) (pp 54-60), 2020. Date of Publication: 01 Feb 2020.. https://dx.doi.org/10.1111/1742-6723.13336

    Graham H., Bakare A.A., Ayede A.I., Oyewole O.B., Gray A., Neal E., Qazi S.A., Duke T., Falade A.G. Diagnosis of pneumonia and malaria in Nigerian hospitals: A prospective cohort study. Pediatric Pulmonology. (no pagination), 2020. Date of Publication: 2020. http://dx.doi.org/10.1002/ppul.24691

    Pukai G. Duke T. Nebulised normal saline in moderate acute bronchiolitis and pneumonia in a low- to middle-income country: a randomised trial in Papua New Guinea. Paediatrics and International Child Health. (no pagination), 2020. Date of Publication: 2020. http://dx.doi.org/10.1080/20469047.2020.1725338

    Girgis A., Millar J., Butt W., d'Udekem Y., Namachivayam S.P. Peak Creatinine, Cardiopulmonary Bypass, and Mortality After Stage 1 Single-Ventricle Reconstruction. Annals of Thoracic Surgery. 109(5):1488-1494, 2020 May.. http://dx.doi.org/10.1016/j.athoracsur.2019.09.026

    Lee A., Butt W. Nitric oxide: a new role in intensive care. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine. 22 (1) (pp 72-79), 2020. Date of Publication: 01 Mar 2020.. https://dx.doi.org/10.1136/archdischild-2019-316956

    Duke T. Lessons from demographic and health surveys on child health and the sustainable development goals: call for papers. Archives of Disease in Childhood. 105(3):209-210, 2020 Mar. https://dx.doi.org/10.1136/archdischild-2019-318353

    Abo, Y.N., Curtis, N., Butters, C., Rozen, T.H., Marais, B.J. and Gwee, A. [Infectious Diseases Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne; Infectious Diseases Group, Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic., Australia.], 'Successful treatment of a severe vision-threatening paradoxical tuberculous reaction with infliximab: first pediatric use', Pediatric Infectious Disease Journal. 39(4):e42-e45, 2020 Apr. https://dx.doi.org/10.1097/INF.0000000000002578

    Schlapbach, L.J., Chiletti, R., Straney, L., Festa, M., Alexander, D., Butt, W., MacLaren, G., Ganeshalingam, A., Sherring, C., Erickson, S., Barr, S., Schibler, A., Long, D., Schlapbach, L., Alexander, J., George, S., Williams, G., Smith, V., Butt, W., Delzoppo, C., Millar, J., Gelbart, B., Oberender, F., Ganu, S., Letton, G., Egan, J., Harper, G. and Festa, M. [Paediatric Intensive Care Unit, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis - A binational multicenter cohort study', Critical Care 2020; vol.23(1), article no. 429

    Namachivayam SP. Invited Commentary. Annals of Thoracic Surgery. 109(4):1267, 2020 Apr. https://dx.doi.org/10.1016/j.athoracsur.2019.09.036

    Butt WW., Chiletti R. ECMO for Neonatal Sepsis in 2019. [Review] Frontiers in Pediatrics. 8:50, 2020. https://dx.doi.org/10.3389/fped.2020.00050

    Sniderman J., MacLaren G. Pulmonary Hypertension and Extracorporeal Membrane Oxygenation-Disparate Causes, Worse Outcomes. Pediatric Critical Care Medicine. 21(3):294-295, 2020 Mar. https://dx.doi.org/10.1097/PCC.0000000000002156 (Impact factor 2.8)

    E Litton, T Bucci, S Chavan, YY Ho, A Holley, G Howard, S Huckson, P Kwong, J Millar, N Nguyen, P Secombe, M Ziegenfuss. D Pilcher. Surge capacity of Australian intensive care units associated with COVID-19 admissions. Med J Aust; https://www.mja.com.au/journal/2020/212/10/surge-capacity-australian-intensive-care-units-associated-covid-19-admissions

    A. Slater, L Straney, J Alexander, D Schell, J Millar. The Effect of Imputation of PaO2/FiO2 From SpO2/FiO2 on the Performance of the Pediatric Index of Mortality 3. Ped Crit Care Med 2020;                                                     doi: 10.1097/PCC.0000000000002233

    Pulsan F., Sobi K., Anga G., Vince J., Duke T. An outbreak of dengue fever in children in the National
    Capital District of Papua New Guinea in 2016. Paediatrics & international Child Health. :1-4, 2020 Apr 24. https://dx.doi.org/10.1080/20469047.2020.1756106

    Olson TL., O'Neil ER., Ramanathan K., Lorusso R., MacLaren G., Anders MM. Extracorporeal membrane oxygenation in peripartum cardiomyopathy: A review of the ELSO Registry. International Journal of Cardiology.  2020 Mar 03 https://dx.doi.org/10.1016/j.athoracsur.2019.09.036

    Wild KT.,,Rintoul N., Kattan J., Gray B., Engle RW., Keene S., Best D., Davis C., DiGeronimo R., Raman L. Extracorporeal Life Support Organization (ELSO): Guidelines for Neonatal Respiratory Failure. ASAIO Journal. 66(5):463-470, 2020 May. https://dx.doi.org/10.1097/MAT.0000000000001153

    Tosif S., Jatobatu A., Maepioh A., Subhi R., Francis KL., Duke T. Cause-specific neonatal morbidity and mortality in the Solomon Islands: An assessment of data from four hospitals over a three-year period. Journal of Paediatrics & Child Health. 56(4):607-614, 2020 Apr. https://dx.doi.org/10.1111/jpc.14699

    Young A., Duke T. The process of implementating child mortality reviews in low and middle income countries: narrative systematic review. Tropical medicine & international health : TM & IH. (no pagination), 2020. Date of Publication: 19 Apr 2020. http://dx.doi.org/10.1111/tmi.13403

    Published works 2019

    Huang J.Y., Ignjatovic V., Sheridan B.J., Mathew J., D'Udekem Y., Brink J., Barton R., Callea G., Morsman D., Donath S., Opat S., Monagle P. ‘Bleeding and thrombotic events occur early in children on durable ventricular assist devices.’  Thrombosis Research. 173 (pp 65-70), January 2019. 

    Gwee A., Cranswick N., McMullan B., Perkins E., Bolisetty S., Gardiner K., Daley A., Ward M., Chiletti R., Donath S., Hunt R., Curtis N. - Continuous Versus Intermittent Vancomycin Infusions in Infants: A Randomized Controlled Trial. Pediatrics.  2019 Jan 30

    Jayaraman K., Adhisivam B., Nallasivan S., Krishnan R., Kamalarathnam C., Bharathi M., McSharry B., Namachivayam S., Shann F.,  Boopalan S., David P.,  Bhat B.V. Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guerin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing <2000g in India. The Pediatric infectious disease journal. 38 (2) (pp 198-202), 2019. Date of Publication: 01 Feb 2019.

    Namachivayam SP., Butt W. Millar J., Konstantinov IE., Nguyen C., d'Udekem Y. Early Peritoneal Dialysis and Major Adverse Events After Pediatric Cardiac Surgery: A Propensity Score Analysis. Pediatr Crit Care Med. 20(2):158-165, 2019 02. https://dx.doi.org/10.1097/PCC.0000000000001793

    Brewster D., Butt W. - Tracheal Intubation in PICU: Making It Safe. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 20 (1) (pp 79-81), 2019. Date of Publication: 01 Jan 2019.

    Huang J.,Ignjatovic V., Sheridan B., Mathew J., D'Udekem Y., Brink J., Barton R., Callea G., Morsman D., Donath S., Opat S., Monagle P. Bleeding and thrombotic events occur early in children on      durable ventricular assist devices. Thrombosis Research. 173:65-70, 2019 01.

    Olita'a D., Barnabas R., Vali Boma G., Pameh W., Vince J., Duke T. Simplified management protocol for term neonates after prolonged rupture of membranes in a setting with high rates of neonatal sepsis and mortality: a quality improvement study. Archives of Disease in Childhood. 104(2):115-120, 2019 Feb. http://dx.doi.org/10.1136/archdischild-2018-315826

    George S., Humphreys S., Williams T., Gelbart B., Chavan A., Rasmussen K., Ganeshalingham A., Erickson S., Ganu S., Singhal N., Foster K., Gannon B., Gibbons K., Schlapbach L., Festa M., Dalziel S.,

    Schibler A., on behalf of the Paediatric Critical Care Research Group (PCCRG), Paediatric Research in Emergency Departments International Collaborative (PREDICT) and the Australia and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG) Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial. BMJ Open 2019 Vol 9(2) :e025997. Epub 2019/02/23. doi: 10.1136/bmjopen-2018-025997. PubMed PMID: 30787094.

    Dagan, M., Butt, W., d'Udekem, Y. and Namachivayam, S.P. [Intensive Care Unit, Cardiac Surgery, Royal Children's Hospital; Murdoch Childrens Research Institute; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Timing of in-hospital

    cardiac arrest after pediatric cardiac surgery: an important metric for quality improvement and prognostication?' J Thorac Cardiovasc Surg. 157(6):e401-e406, 2019 06. https://dx.doi.org/10.1016/j.jtcvs.2019.01.066

    Dagan, M., D'Udekem, Y., Thompson, J., Butt, W. and Namachivayam, S.P. [Intensive Care Unit, Cardiac Surgery, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Timing of in-hospital cardiac arrest following paediatric cardiac surgery influences outcomes', Pediatric Critical Care Medicine 2018; vol.19(6S), pp.7

    Gwee, A., Cranswick, N., McMullan, B., Perkins, E., Bolisetty, S., Gardiner, K., Daley, A., Ward, M.,

    Chiletti, R., Donath, S., Hunt, R. and Curtis, N. [Department of Paediatrics, University of

    Melbourne; Royal Children's Hospital; Murdoch Childrens Research Institute, Flemington Road,

    Parkville, Vic., Australia.], 'Continuous versus intermittent vancomycin infusions in infants: a

    randomized controlled trial', Pediatrics 2019; vol.143(2), e20182179

    Prentice, T., Kausman, J., Gelbart, B. ‘Neonatal Organ Donation.’ New England Journal of Medicine. 380(8):798, 2019 02 21. doi: 10.1056/NEJMc1900119. PubMed PMID: 30789682.

    Weiss, M.J., Perez Blanco, A. and Gelbart, B. [Department of Paediatrics, University of Melbourne;

    Intensive Care Unit, Royal Children's Hospital; Murdoch Childrens Research Institute, Flemington

    Road, Parkville, Vic., Australia.], 'Special issues in pediatric deceased organ donation', ’ Intensive Care Medicine. 45(3):361-363, 2019 Mar. doi: 10.1007/s00134-019-05523-2. PubMed PMID: 30725135. https://dx.doi.org/10.1007/s00134-019-05523-2

    Khoo B., Buratto E., Fricke TA., Gelbart B., Brizard CP., Brink J., d'Udekem Y., Konstantinov IE. Outcomes of surgery for infective endocarditis in children: A 30-year experience. Journal of Thoracic & Cardiovascular Surgery.  2019 Jun 20. https://dx.doi.org/10.1016/j.jtcvs.2019.06.024

    Weiss M.J., Dominguez-Gil B., Lahaie N.,  Nakagawa T.A., Scales A., Hornby L., Green M., Gelbart B.,  Hawkins K., Dhanani S., Dipchand A.I., Shemie S.D. Development of a multinational registry of pediatric deceased organ donation activity. Pediatric Transplantation. 23 (3) (no pagination), 2019. Article Number: e13345. Date of Publication: May 2019. doi: 10.1111/petr.13345. PubMed PMID: 30724003.

    Moynihan, K.M., Alexander, P.M.A., Schlapbach, L.J., Millar, J., Jacobe, S., Ravindranathan, H., Croston, E.J., Staffa, S.J., Burns, J.P. and Gelbart, B. [Department of Paediatrics, University of Melbourne; Royal Children's Hospital; Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic., Australia.], 'Epidemiology of childhood death in Australian and New Zealand intensive care units', Intensive Care Medicine 2019; [Epub ahead of print]

    Soquet, J., Chiletti, R., Horton, S., Konstantinov, I., Brink, J.,  Brizard, C., Butt, W., d'Udekem, Y. ‘Dismal Outcomes of Second-Run Extracorporeal Life Support in the Paediatric Population.’ Heart, Lung & Circulation. 28(3):450-454, 2019 Mar.

    Jones S., Butt W., Monagle P., Cain T., Newall F. ‘The natural history of asymptomatic central venous      catheter-related thrombosis in critically ill children.’ Blood. 133 (8) (pp 857-866), 2019. Date of Publication: 21 Feb 2019.

    Pulsan F., Sobi K.,  Duke T. ‘Continuous positive airway pressure in children with severe       pneumonia and hypoxaemia in Papua New Guinea: an implementation evaluation.’ Acta Paediatrica. 108(10):1887-1895, 2019 10. https://dx.doi.org/10.1111/apa.14796

    Bakare A.,  Graham H.,  Ayede A.,  Peel D.,  Olatinwo O.,  Oyewole O.,  Fowobaje K.,  Qazi S.,

    Izadnegahdar R., Duke T., Falade A. ‘Providing oxygen to children and newborns: a multi-faceted       technical and clinical assessment of oxygen access and oxygen use in secondary-level hospitals in southwest Nigeria.’ International Health.  2019 Mar 21

    Barbaro R.,  MacLaren G. ‘Improving Pediatric Extracorporeal Cardiopulmonary Resuscitation Means Delivering Best Care and Measuring Impact Beyond Survival.’ Critical Care Medicine. 47(4):613-615, 2019 Apr.

    Morre R., Sobi K., Pameh W., Ripa P., Vince J., Duke T. ‘Safety, Effectiveness and Feasibility of Outpatient Management of Children with Pneumonia with Chest Indrawing at Port Moresby       General Hospital, Papua New Guinea.’ Journal of Tropical Pediatrics. 65 (1) (pp 71-77), 2019. Date of Publication: 07 Feb 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366396

    Jayaraman, K., Adhisivam, B., Nallasivan, S., Krishnan, R.G., Kamalarathnam, C., Bharathi, M., McSharry, B., Namachivayam, S.P., Shann, F., Boopalan, S.I., David, P. and Bhat, B.V. [Paediatric Intensive Care Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne; Murdoch Childrens Research Institute, Parkville, Vic., Australia.], 'Two randomized trials of the effect of the Russian strain of Bacillus Calmette-Guerin alone or with oral polio vaccine on neonatal mortality in infants weighing <2000g in India', Pediatric Infectious Disease Journal 2019; vol.38(2), pp.198-202 https://dx.doi.org/10.1097/INF.0000000000002198

    Brewster, D.J. and Butt, W. [Intensive Care Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Tracheal intubation in PICU: making it safe', Pediatric Critical Care Medicine 2019; vol.20(1), pp.79-81 Date of Publication: 01 Jan 2019. http://dx.doi.org/10.1097/PCC.0000000000001791

    Barbaro, R.P. and MacLaren, G. [Paediatric Intensive Care Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Improving pediatric extracorporeal cardiopulmonary resuscitation means delivering best care and measuring impact beyond survival', Critical Care Medicine 2019; vol.47(4), pp.613-615 http://dx.doi.org/10.1097/CCM.0000000000003673

    Duke, T., Irimu, G. and Were, W. [Department of Paediatrics, University of Melbourne; Intensive Care Unit, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'New WHO guidelines on paediatric mortality and morbidity auditing', Archives of Disease in Childhood 2019; Mar 12 [Epub ahead of print]

    Cortina, G., McRae, R., Hoq, M., Donath, S., Chiletti, R., Arvandi, M., Gothe, R.M., Joannidis, M. and Butt, W. [Paediatric Intensive Care Unit, Royal Children's Hospital; Murdoch Childrens Research Institute; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Mortality of critically ill children requiring continuous renal replacement therapy: Effect of fluid overload, underlying disease, and timing of initiation', Pediatric Critical Care Medicine 2019; vol.20(4), pp.314-322 https://dx.doi.org/10.1097/PCC.0000000000001806

    Mond, C., Duke, T. and Vince, J. [Department of Paediatrics, University of Melbourne; Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Epilepsy in Papua New Guinea: a longitudinal cohort study', Arch Dis Child. 104(10):941-946, 2019 10. https://dx.doi.org/10.1136/archdischild-2019-317217

    Schlapbach LJ., Horton SB.,  Long DA.,  Beca J., Erickson S., Festa M.,  d'Udekem Y., Alphonso N.,  Winlaw D., Johnson K., Delzoppo C., van Loon K., Gannon B., Fooken J., Blumenthal A., Young P.,  Jones M.,  Butt W.,  Schibler A. Study protocol: NITric oxide during cardiopulmonary bypass to      improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial. BMJ Open. 9(8):e026664, 2019 08 15. https://dx.doi.org/10.1136/bmjopen-2018-026664

    Duke T., Irimu G., Were W. New WHO guidelines on paediatric mortality and morbidity auditing.

    Archives of Disease in Childhood. 104(9):831-832, 2019 Sep 09. https://dx.doi.org/10.1136/archdischild-2019-316956

    Sosnin N., Curtis N., Cranswick N., Chiletti R.,  Gwee A. Vancomycin is commonly under-dosed in critically ill children and neonates. Br J Clin Pharmacol. 85(11):2591-2598, 2019 Nov. http://dx.doi.org/10.1111/bcp.14084

    Kauna R., Sobi K.,  Pameh W., Vince J.D., Duke T. Oral Rehydration in Children with Acute Diarrhoea and Moderate Dehydration-Effectiveness of an ORS Tolerance Test. Journal of tropical pediatrics. (no pagination), 2019. Date of Publication: 16 Apr 2019.

    Yaw H.P., Van Den Helm S., Barton R., Newall F., D'Udekem Y., Horton S., Maclaren G., Chiletti R., Johansen A., Best D., McKittrick J., Butt W., Monagle P., Ignjatovic V., Linden M. Platelet phenotype and function in paediatric extracorporeal membrane oxygenation (ECMO) circuits. Research and Practice in Thrombosis and Haemostasis. Conference: 27th Congress of the International Society on Thrombosis and Haemostasis. Australia. 3 (Supplement 1) (pp 516-517), 2019. Date of Publication: July 2019.

    Van Den Helm S., Barton R., Yaw H.P., Letunica N., Newall F., D 'Udekem Y., Horton S., MacLaren G., - Chiletti R., Johansen A., Best D., McKittrick J., Butt W., Linden M., Monagle P., Ignjatovic V. Bleeding and clotting in children on ecmo at the Royal Children's Hospital: A two year summary. Research and Practice in Thrombosis and Haemostasis. Conference: 27th Congress of the International Society on Thrombosis and Haemostasis. Australia. 3 (Supplement 1) (pp 514-515), 2019. Date of Publication: July 2019.

    Yaw H.P., Van Den Helm S., Barton R., Newall F., D'Udekem Y., Horton S., Maclaren G., Chiletti R., Johansen A., Best D., McKittrick J., Butt W., Monagle P.,  Ignjatovic V., Linden M. Platelet physiology and function in neonates and children from different pathways onto extracorporeal membrane oxygenation (ECMO). Research and Practice in Thrombosis and Haemostasis. Conference: 27th Congress of the International Society on Thrombosis and Haemostasis. Australia. 3 (Supplement 1) (pp 136-137), 2019. Date of Publication: July 2019.

    Duke, T. [Centre for International Child Health, Department of Paediatrics, University of Melbourne; Murdoch Childrens Research Institute; Intensive Care Unit, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'What the PERCH study means for future pneumonia strategies', Lancet 2019; [Epub ahead of print]

    Kauna, R., Sobi, K., Pameh, W., Vince, J.D. and Duke, T. [Centre for International Child Health, Department of Paediatrics, University of Melbourne; Royal Children's Hospital; Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic., Australia.], 'Oral rehydration in children with acute diarrhoea and moderate dehydration-effectiveness of an ORS tolerance test', - Journal of Tropical Pediatrics. 65 (6) (pp 583-591), 2019. Date of Publication: 18 Mar 2019. http://dx.doi.org/10.1093/tropej/fmz017

    Ramanathan, K., Tan, C.S., Rycus, P. and MacLaren, G. [Paediatric Intensive Care Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Extracorporeal membrane oxygenation for severe adenoviral pneumonia in neonatal, pediatric, and adult patients', Pediatr Crit Care Med. 20(11):1078-1084, 2019 Nov. https://dx.doi.org/10.1097/PCC.0000000000002047

    Duke, T. [Paediatric Intensive Care Unit, Royal Children's Hospital; Centre for International Child Health, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'CPAP and high-flow oxygen to address high mortality of very severe pneumonia in low-income countries - keeping it in perspective', Paediatrics and International Child Health 2019; vol.39(3), pp.155-159 (full text via Document Delivery) https://dx.doi.org/10.1080/20469047.2019.1613782

    Bakare AA., Graham H., Ayede AI., Peel D., Olatinwo O., Oyewole OB., Fowobaje KR., Qazi S.,  Izadnegahdar R., Duke T., Falade AG. Providing oxygen to children and newborns: a multi-faceted

    technical and clinical assessment of oxygen access and oxygen use in secondary-level hospitals in southwest Nigeria. International Health.  2019 Mar 21

    Stukas S., Higgins V., Frndova H., Gill J., Hubara E., Guerguerian AM., Boutis K., Beauchamp M., Farrell C., Babl FE., Delzoppo C., Greenham M., Wilkinson AA., Crichton A., Anderson V., Adeli K., Hutchison J., Wellington C. Characterisation of serum total tau following paediatric  traumatic brain injury: a case-control study. The Lancet Child & Adolescent Health. 3(8):558-567, 2019 Aug.

    Ashraf H., Alam NH., Sultana M., Jahan SA., Begum N., Farzana S., Chisti MJ., Kamal M., Shamsuzzaman A., Ahmed T., Khan JAM., Fuchs GJ., Duke T., Gyr N. Day clinic vs. hospital care of pneumonia and severe malnutrition in children under five: a randomised trial. Tropical Medicine & International Health. 24(7):922-931, 2019 Jul.

    Long E., Babl F.E., Oakley E., Hopper S., Sheridan B., Duke T. Does fluid bolus therapy increase blood pressure in children with sepsis?. EMA - Emergency Medicine Australasia. (no pagination), 2019. Date of Publication: 2019.

    Duke T., Wong NX. Antimicrobial resistance: think globally but act locally. Archives of Disease in Childhood.  2019 Sep 27

    Tibballs J. Australian snake antivenom dosing: What is scientific and safe?. Anaesthesia & Intensive Care. :310057X19865268, 2019 Sep 10 

    Murni IK., Duke T., Daley AJ., Kinney S., Soenarto Y., Kinney, S. Predictors of mortality in children with nosocomial bloodstream infection. Paediatrics & international Child Health. 39(2):119-123, 2019 05.

    Girgis, A., Millar, J., Butt, W., d'Udekem, Y. and Namachivayam, S.P. [Intensive Care Unit, Cardiac Surgery, Royal Children's Hospital; Murdoch Childrens Research Institute; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], Peak creatinine, cardiopulmonary bypass and mortality after stage one single-ventricle reconstruction. Annals of Thoracic Surgery 2019; Oct 12 [Epub ahead of print]

    Yaw, H.P., Van Den Helm, S., MacLaren, G., Linden, M., Monagle, P. and Ignjatovic, V. [Department of Haematology Research, Murdoch Childrens Research Institute; Department of Paediatrics, University of Melbourne; Paediatric Intensive Care Unit, Department of Clinical Haematology, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Platelet phenotype and function in the setting of pediatric extracorporeal membrane oxygenation (ECMO): a systematic review', Frontiers in Cardiovascular Medicine 2019; vol.6, article no. 137

    Namachivayam SP. Impact of Gestational Age on Surgical Outcomes in Patients with Functionally Single Ventricle (Commentary). Annals of Thoracic Surgery.  2019 Oct 31 https://dx.doi.org/10.1016/j.athoracsur.2019.09.036

    Luo, J., Duke, T., Chisti, M.J., Kepreotes, E., Kalinowski, V. and Li, J. [Centre for International Child Health, Department of Paediatrics, University of Melbourne; Murdoch Childrens Research Institute; Intensive Care Unit, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Efficacy of high-flow nasal cannula vs standard oxygen therapy or nasal continuous positive airway pressure in children with respiratory distress: a meta-analysis', Journal of Pediatrics. 215 (pp 199-208.e8), 2019. Date of Publication: December 2019. http://dx.doi.org/10.1016/j.jpeds.2019.07.059

    Farrell, D., MacLaren, G. and Schlapbach, L.J. [Department of Paediatrics, University of Melbourne; Royal Children's Hospital, Flemington Road, Parkville Vic., Australia], 'Infections on extracorporeal life support in adults and children- a survey of international practice on prevention, diagnosis, and treatment', Pediatric Critical Care Medicine 2019; vol.20(7), pp.667-671

    Laussen, P.C., Assadi, A., Moga, M.A. and MacLaren, G. [Department of Paediatrics, University of Melbourne; Paediatric Intensive Care Unit, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Challenges for cardiopulmonary resuscitation in infants and children with cardiac disease in the perioperative setting', Journal of Cardiothoracic and Vascular Anesthesia 2019; vol.33(10), pp.2618-2621

    Butt, W. [Intensive Care Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne; Intensive Care Group Research, Clinical Sciences Theme, Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic., Australia.], 'Consensus clinical practice guidelines-are they worth the effort!', Pediatric Critical Care Medicine 2019; vol.20(8), pp.773-774

    Butt, W. [Intensive Care Unit, Royal Children's Hospital; Murdoch Childrens Research Institute; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Outcome measures after ICU-what now?', Pediatric Critical Care Medicine 2019; vol.20(8), pp.778-779

    Butt, W. [Intensive Care, Royal Children's Hospital; Department of Paediatrics, University of Melbourne; ICU Research Clinical Sciences Theme, Murdoch Childrens Research Center, Flemington Road, Parkville, Vic., Australia.], 'Bleeding after cardiac surgery: multiple strategies and teamwork are essential!', Perfusion. 34(8):637-639, 2019 11.- https://dx.doi.org/10.1177/0267659119867196

    Khoo, B., Buratto, E., Fricke, T.A., Gelbart, B., Brizard, C.P., Brink, J., d'Udekem, Y. and Konstantinov, I.E. [Department of Cardiac Surgery, Department of Intensive Care, Royal Children's Hospital; Department of Paediatrics, University of Melbourne; Melbourne Children's Centre for Cardiovascular Genomics and Regenerative Medicine, Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic., Australia.], 'Outcomes of surgery for infective endocarditis in children: a 30-year experience', J Thorac Cardiovasc Surg. 2019;158(5):1399-409. Epub 2019/08/07.                                        https://dx.doi.org/10.1016/j.jtcvs.2019.06.024 PubMed PMID: 31383559.

    Schlapbach, L.J., Horton, S.B., Long, D.A., Beca, J., Erickson, S., Festa, M., d'Udekem, Y., Alphonso, N., Winlaw, D., Johnson, K., Delzoppo, C., van Loon, K., Gannon, B., Fooken, J., Blumenthal, A., Young, P., Jones, M., Butt, W., Schibler, A., Nitric Study Group, The Australian and New Zealand New Zealand Intensive Care Society Clinical Trials Group, The Paediatric Critical Care Research Group (PCCRG) and The ANZICS Paediatric Study Group (PSG). [Cardiac Surgical Unit, Department of Cardiac Surgery, Pediatric Intensive Care Unit, Royal Children's Hospital; Department of Paediatrics, University of Melbourne; Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic., Australia.], 'Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial', BMJ Open 2019; vol.9(8), pp.e026664

    Van Den Helm, S., Barton, R., Yaw, H.P., Letunica, N., Newall, F., Y, D.U., Horton, S., MacLaren, G., Chiletti, R., Johansen, A., Best, D., McKittrick, J., Butt, W., Linden, M., Monagle, P. and Ignjatovic, V. [Haematology Research, Heart Research Group, Murdoch Childrens Research Institute; Department of Paediatrics, University of Melbourne; Department of Clinical Haematology, Department of Cardiac Surgery, Department of Perfusion, Department of Intensive Care, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.], 'Bleeding and clotting in children on ecmo at the Royal Children's Hospital: a two year summary', Research and Practice in Thrombosis and Haemostasis 2019; vol.3(Suppl. 1), pp.514-515

    Butt W. Extubation Failure After Cardiac Surgery: Can It Be Used As a Metric for Quality Improvement and/or Comparison of Patient Outcomes. - Pediatr Crit Care Med. 20(5):495-496, 2019 05.

    Crichton AJ., Ignjatovic V., Babl F., Oakley E., Greenham M., Hearps SJC., Delzoppo C., Beauchamp MH., Guerguerian AM., Boutis K., Hubara EH., Hutchison JS., Anderson V. Interleukin-8 Predicts Fatigue at 12 Months Post-injury in Children with Traumatic Brain Injury. Journal of Neurotrauma.  2019 Dec 27. - http://dx.doi.org/10.1089/neu.2018.6083

    Tosif S., Jatobatu A., Maepioh A., Subhi R., Francis KL., Duke T. Cause-specific neonatal morbidity and mortality in the Solomon Islands: An assessment of data from four hospitals over a three-year period. Journal of Paediatrics & Child Health.  2019 Dec http://dx.doi.org/10.1111/jpc.14699

    Long E., O'Brien A., Duke T., Oakley E., Babl FE. Effect of Fluid Bolus Therapy on Extravascular Lung Water Measured by Lung Ultrasound in Children With a Presumptive Clinical Diagnosis of Sepsis. - J Ultrasound Med. 38(6):1537-1544, 2019 Jun. - http://dx.doi.org/10.1002/jum.14842

    Graham H., Bakare AA., Ayede AI., Oyewole OB., Gray A., Peel D., McPake B., Neal E., Qazi SA., Izadnegahdar R., Duke T., Falade AG. Hypoxaemia in hospitalised children and neonates: A      prospective cohort study in Nigerian secondary-level hospitals.  EClinicalMedicine. 16:51-63, 2019 Nov. http://dx.doi.org/10.1016/j.eclinm.2019.10.009

    Butt W. Bleeding after cardiac surgery: multiple strategies and teamwork are essential!. Perfusion. 34(8):637-639, 2019 11.  https://dx.doi.org/10.1177/0267659119867196

    Graham H.R., Bakare A.A., Ayede A.I., Gray A.Z., McPake B., Peel D., Olatinwo O., Oyewole O.B., Neal E.F.G., Nguyen C.D., Qazi S.A., Izadnegahdar R., Carlin J.B., Falade A.G., Duke T. Oxygen systems to improve clinical care and outcomes for children and neonates: A stepped-wedge cluster-randomised trial in Nigeria. PLoS Medicine. 16 (11) (no pagination), 2019. Article Number: e1002951. Date of Publication: 2019. http://dx.doi.org/10.1371/journal.pmed.1002951

    Dagan M., Butt W., Millar J., d'Udekem Y., Thompson J., Namachivayam SP. Changing Risk of In-Hospital Cardiac Arrest in Children Following Cardiac Surgery in Victoria, Australia, 2007-2016. Heart, Lung & Circulation. 28(12):1904-1912, 2019 Dec. http://dx.doi.org/10.1016/j.hlc.2018.11.003

    Moynihan KM., Alexander PMA., Schlapbach LJ., Millar J., Jacobe S., Ravindranathan H., Croston EJ.,  Staffa SJ., Burns JP., Gelbart B. Epidemiology of childhood death in Australian and New Zealand      intensive care units. Intensive Care Medicine. 45(9):1262-1271, 2019 09.

    Sheridan B., Butt W., MacLaren G. ECMO in Single Ventricle Heart Disease. Current Treatment Options in Pediatrics. 5 (4) (pp 356-367), 2019. Date of Publication: 01 Dec 2019. -http://dx.doi.org/10.1007/s40746-019-00173-4 ,  - http://www.springer.com/medicine/pediatrics/journal/40746

    Gelbart B, Bitker L, Segal A, Hutchinson A, Soh N, Maybury T. Haemodynamic response to fluid boluses in children after cardiac surgery: a technical report. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine. 2019;21(2):132-8. Epub 2019/05/31. PubMed PMID: 31142244.

    Schlapbach LJ, Gelbart B, Festa M, Australian, New Zealand Intensive Care Society Paediatric Study G, Kanthimathinathan HK, et al. Global paediatric critical care research: mind the gaps. Intensive Care Med. 2019;45(5):753-4. Epub 2019/03/07. doi: 10.1007/s00134-019-05571-8. PubMed PMID: 30840117.

    Morin, L., Kneyber, M., Jansen, N.J.G., Peters, M.J., Javouhey, E., Nadel, S., Maclaren, G., Schlapbach, L.J., Tissieres, P., The ESPNIC Refractory Septic Shock Definition taskforce and The Infection Systemic Inflammation and Sepsis ESPNIC section. [Royal Children’s Hospital; Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Vic., Australia.], 'Translational gap in pediatric septic shock management: an ESPNIC perspective', Annals of Intensive Care 2019; vol.9, article no. 73

    Chiletti R., Kenna K., Smolich J., Bennett M., Stephanie P., Brink J., Zannino D., Angerosa J., Pepe S., Cheung M. Effect of S-nitrosoglutathione on cardiovascular dysfunction in a paediatric animal model of cardiopulmonary bypass. Circulation. Conference: American Heart Association Scientific Sessions, AHA 2019. United States. 140 (Supplement 1) (no pagination), 2019. Date of Publication: 2019. http://dx.doi.org/10.1161/circ.140.suppl_1.13815

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